منابع مشابه
Endogenous ouabain is not ouabain.
T he concept of a circulating digitalis-like inhibitor of the sodium pump, Na + , K +-ATPase, evolved from studies performed in the 1960s. De Wardener et al 1 addressed the question of whether a small increase in the glomerular filtration rate together with changes in the concentration of the more recently discovered hormone aldosterone could explain the natriuresis that generally followed salt...
متن کاملEndogenous Ouabain
In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid hormone. This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases. Novel ouabain-resistant mice that elucidate the key roles of α2 Na pumps and their cardioto...
متن کاملStructure of `endogenous ouabain'*
The structural characterization of the ouabain-like sodium pump inhibitor in mammals (so-called `endogenous ouabain') has long been hindered by the paucity of the sample material. While many microscale structural analyses, including LC/MS and sugar analysis, could not differentiate `endogenous ouabain' from ouabain, our past nanogram-scale `pentanaphthoylation' followed by HPLC and circular dic...
متن کاملIs ouabain the endogenous digitalis?
T he possibility that an endogenous ligand might exist for the cardiac glycoside binding site on the Na+,K+-ATPase (i.e., the "sodium pump") has been a source of much speculation, resulting in intensive efforts over the past decade by many laboratories to identify an "endogenous digitalis-like hormone."'1-6 Several arguments have been propounded in support of this hypothesis. The first and perh...
متن کاملEndogenous ouabain regulates cell viability.
The endogenous cardiac steroid-like compounds, endogenous ouabain (EO) in particular, are present in the human circulation and are considered putative ligands of the inhibitory binding site of the plasma membrane Na(+)-K(+)-ATPase. A vast amount of data shows that, when added to cell cultures, these steroids promote the growth of cardiac, vascular, and epithelial cells. However, the involvement...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 2016
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.116.06599